At the start of 2025, we want to recap some of the Brown Lab highlights from 2024!

Graduations:

  • Lab alumni Grant Scull and Halston Deal defended their PhD theses!

Awards:

  •  Fifth-year student Aryssa Simpson was award the Joint Department of Biomedical | North Carolina State University and University of North Carolina – Chapel Hill Graduate Student Service Award in addition to joining the Scientist Mentoring & Diversity Program (SMDP) and the International Center for Professional Development (ICPD) as a Biotech Scholar
  • Fourth-year student Halle Cantor was awarded an F30 award to support her progress towards her combined DVM/PhD degree
  • Second-year student Krista Hilmas received support from the T32-funded Comparative Molecular Medicine Training Program
  • Post-Doc Nooshin Zandi, fourth-year Halle Cantor, second-year students Ethan Pozy and Krista Hilmas, and first-year student Elizabeth Byrnes all were funded for research proposals submitted to the  Summer Interdisciplinary Research Initiative (SIRI)/American Heart Association CMI Summer Undergraduate Research projects

Publications:

  1. Pozy E, Brown AC. Transfusion biomaterials for hemostasis. Journal of Thrombosis and Haemostasis 2024. https://doi.org/10.1016/j.jtha.2024.11.030
  2. Oshinowo, O., Copeland, R., Patel, A., Shaver, N., Fay, M., Jeltuhin, R., Xiang, Y., Caruso, C., Otumala, A., Hernandez, S., Delgado, P., Dean, G., Kelvin, J., Chester, D., Brown, A.C., Dreaden, E., Leong, T., Waggoner, J., Li, R., Ortlund, E., Bennett, C., Lam, W, Myers, D+. Autoantibodies immune-mechanically modulate platelet contractile force and bleeding risk. Nature Communications. 2024, 15, 10201. doi.org/10.1038/s41467-024-54309-8.
  3. Deal, H., Byrnes, E., Pandit, S., Sheridan, A., Brown, A.C.+, Daniele, M.+ Injury-on-chip for modelling microvascular trauma-induced coagulation. Lab on Chip. Accepted.
  4. Palomino, T., Sheridan, A., Muddiman, D., Brown, A.C.+ In-depth characterization of N-glycosylation and sialic acid content in fetal and adult fibrinogen. Research and Practice in Thrombosis and Haemostasis. Accepted.
  5. Ozawa, S.+, Pierce, K., Thomson, A., Moiseiwitsch, N., Stephens, J., LeGrand, J. Brown, A.C., Hiroyuki, M. Point-of-care cardiac troponin I (cTnI) assay evaluation in New Zealand White rabbits. JAALAS. In Press.
  6. Sheridan, A., Nellenbach, K., Pandit, S., Byrnes, E., Hardy, G., Lutz, H., Moiseiwitsch, N., Scull, G., Mihalko, E., Levy, J. Brown, A.C.+ Clot-targeted nanogels for dual-delivery of anti-thrombinIII and tissue plasminogen activator to mitigate disseminated intravascular coagulation complications. ACS Nano. 2024, 18, 24, 15517-15528. Doi: 10.1021/acsnano.4c00162.
  7. Scull, G., Aligwekwe, A., Rey, Y., Koch, D., Nellenbach, K., Sheridan, A., Pandit, S., Sollinger, J., Pierce, J., Flick, M. Gilbertie, J., Schnabel, L., Brown, A.C.+ Fighting fibrin with fibrin: vancomycin delivery into coagulase-mediated S. aureus biofilms via fibrin-based nanoparticle binding. JBMR A. 2024, doi: 10.1002/jbm.a.37760
  8. Simpson, A., Mihalko, E., Fox, C., Sridharan, S., Krishnakumar, M., Brown, A.C.+ Biomaterial systems for evaluating the influence of ECM mechanics on anti-fibrotic therapeutic efficacy. Matrix Biology Plus. 2024, 23 doi: 10.1016/j.mbplus.2024.100150.
  9. Zandi, N., Daniele, M., Brown, A.C.+ Advances in Fibrin-Based Bioprinting for Skin Tissue Regeneration: Exploring Design, and Innovative Approaches. Biomedical Devices and Materials, 2024. Doi: 10.1007/s44147-024-00198-w.
  10. Downey, L, Moiseiwitsch, N., Nellenbach, K., Xiang, Y., Brown, A.C., Guzzetta, N. Effect of in
    vivo administration of fibrinogen concentrate versus cryoprecipitate on ex vivo clot degradation in neonates undergoing cardiac surgery. Anesthesia & Analgesia., 2024 In Press.
  11. Krissanaprasit, A., Mihalko, E., Meinhold, K., Simpson, A., Dupont, D., Kjems, J., Brown, A.C., LaBean, T. A functional RNA-Origami as Direct Thrombin Inhibitor with Fast-acting and Specific Single-Molecule Reversal Agents in vivo model. Molecular Therapy. 2024. Doi:10.1016 j.ymthe.2024.05.002.
  12. Nellenbach K., Nandi, S., Mihalko, E., Koch, D., Shetty, J., Sollinger, J., Moiseiwitsch, N., Sheridan, A., Hoffman, M., Schnabel, L., Lyon, A., Barker, T., and Brown, A.C.+ Ultrasoft platelet-like particles stop bleeding after trauma and exhibit unexpected clearance mechanisms. Science Translational Medicine. 2024. DOI: 10.1126/scitranslmed.adi4490
  13. Simpson, S., Krissanaprasit, A., Chester, D., LaBean, T., Brown, A.C.+ Utilizing multiscale engineered systems to examine TGFβ mediated myofibroblastic differentiation. 2024. Wound Repair and Regeneration. DOI: 10.1111/wrr.13168
  14. Davis, Z., Koch, D., Watson, S., Scull, G., Brown, A.C., Schnabel, L., Fisher, M + Controlled stiffness of direct-write, near-field electrospun gelatin fibers generates differences in tenocyte morphology and gene expression. Journal of Biomechanical Engineering. 2024. doi.org/10.1115/1.4065163.
  15. Kilgore R. E., Moore B. D., Sripada S. A., Chu W., Shastry S., Barbieri E., Hu S., Tian W., Petersen H., Mohammadifar M., Simpson A., Brown A.C., Lavoie J., Elhanafi D., Goletz S., Cheng K., Daniele M. A., Menegatti S. (2024). Peptide ligands for the universal purification of exosomes by affinity chromatography. Biotechnology and Bioengineering. doi.org/10.1002/bit.28821.

Other Publications by Lab Members:

  1. Liu S, Popowski K, Li J, Jing Y, Silkstone D, Belcher E, Cislo M, Hu S, Lutz H, Ghodsi A, Liu M, Dinh PUC, Cheng K*. Inhalable hsa-miR-30a-3p liposomes attenuate pulmonary fibrosis. Advanced Science. 27 Nov 2024.
  2. Li J, Sun S, Zhu D, Mei X, Huang K, Li Y, Liu S, Lyu Y, Wang Z, Hu S, Lutz H, Dinh PUC, Popowski K, Butte A, Cheng K*. Inhalable Stem Cell Exosome Modulates Endothelial CD36 for Enhanced Cardiac Repair in Rodent and Swine Models of Myocardial Infarction. Circulation. 01 Mar 2024.
  3. H.A. Miller, A. Priester, E. Curtis, K.Hilmas, A. Abbott, F. Kievit, A.J. Convertine. “Optimized gadolinium-DO3A loading in RAFT-polymerized copolymers for superior MR imaging of aging blood-brain barrier” Sensors and Diagnostics. (2024)