Brown Lab

Advanced Wound Healing Lab

Brown Lab 2024 In-Review: Awards and Publications

At the start of 2025, we want to recap some of the Brown Lab highlights from 2024!

Graduations:

  • Lab alumni Grant Scull and Halston Deal defended their PhD theses!

Awards:

  •  Fifth-year student Aryssa Simpson was award the Joint Department of Biomedical | North Carolina State University and University of North Carolina – Chapel Hill Graduate Student Service Award in addition to joining the Scientist Mentoring & Diversity Program (SMDP) and the International Center for Professional Development (ICPD) as a Biotech Scholar
  • Fourth-year student Halle Cantor was awarded an F30 award to support her progress towards her combined DVM/PhD degree
  • Second-year student Krista Hilmas received support from the T32-funded Comparative Molecular Medicine Training Program
  • Post-Doc Nooshin Zandi, fourth-year Halle Cantor, second-year students Ethan Pozy and Krista Hilmas, and first-year student Elizabeth Byrnes all were funded for research proposals submitted to the  Summer Interdisciplinary Research Initiative (SIRI)/American Heart Association CMI Summer Undergraduate Research projects

Publications:

  1. Pozy E, Brown AC. Transfusion biomaterials for hemostasis. Journal of Thrombosis and Haemostasis 2024. https://doi.org/10.1016/j.jtha.2024.11.030
  2. Oshinowo, O., Copeland, R., Patel, A., Shaver, N., Fay, M., Jeltuhin, R., Xiang, Y., Caruso, C., Otumala, A., Hernandez, S., Delgado, P., Dean, G., Kelvin, J., Chester, D., Brown, A.C., Dreaden, E., Leong, T., Waggoner, J., Li, R., Ortlund, E., Bennett, C., Lam, W, Myers, D+. Autoantibodies immune-mechanically modulate platelet contractile force and bleeding risk. Nature Communications. 2024, 15, 10201. doi.org/10.1038/s41467-024-54309-8.
  3. Deal, H., Byrnes, E., Pandit, S., Sheridan, A., Brown, A.C.+, Daniele, M.+ Injury-on-chip for modelling microvascular trauma-induced coagulation. Lab on Chip. Accepted.
  4. Palomino, T., Sheridan, A., Muddiman, D., Brown, A.C.+ In-depth characterization of N-glycosylation and sialic acid content in fetal and adult fibrinogen. Research and Practice in Thrombosis and Haemostasis. Accepted.
  5. Ozawa, S.+, Pierce, K., Thomson, A., Moiseiwitsch, N., Stephens, J., LeGrand, J. Brown, A.C., Hiroyuki, M. Point-of-care cardiac troponin I (cTnI) assay evaluation in New Zealand White rabbits. JAALAS. In Press.
  6. Sheridan, A., Nellenbach, K., Pandit, S., Byrnes, E., Hardy, G., Lutz, H., Moiseiwitsch, N., Scull, G., Mihalko, E., Levy, J. Brown, A.C.+ Clot-targeted nanogels for dual-delivery of anti-thrombinIII and tissue plasminogen activator to mitigate disseminated intravascular coagulation complications. ACS Nano. 2024, 18, 24, 15517-15528. Doi: 10.1021/acsnano.4c00162.
  7. Scull, G., Aligwekwe, A., Rey, Y., Koch, D., Nellenbach, K., Sheridan, A., Pandit, S., Sollinger, J., Pierce, J., Flick, M. Gilbertie, J., Schnabel, L., Brown, A.C.+ Fighting fibrin with fibrin: vancomycin delivery into coagulase-mediated S. aureus biofilms via fibrin-based nanoparticle binding. JBMR A. 2024, doi: 10.1002/jbm.a.37760
  8. Simpson, A., Mihalko, E., Fox, C., Sridharan, S., Krishnakumar, M., Brown, A.C.+ Biomaterial systems for evaluating the influence of ECM mechanics on anti-fibrotic therapeutic efficacy. Matrix Biology Plus. 2024, 23 doi: 10.1016/j.mbplus.2024.100150.
  9. Zandi, N., Daniele, M., Brown, A.C.+ Advances in Fibrin-Based Bioprinting for Skin Tissue Regeneration: Exploring Design, and Innovative Approaches. Biomedical Devices and Materials, 2024. Doi: 10.1007/s44147-024-00198-w.
  10. Downey, L, Moiseiwitsch, N., Nellenbach, K., Xiang, Y., Brown, A.C., Guzzetta, N. Effect of in
    vivo administration of fibrinogen concentrate versus cryoprecipitate on ex vivo clot degradation in neonates undergoing cardiac surgery. Anesthesia & Analgesia., 2024 In Press.
  11. Krissanaprasit, A., Mihalko, E., Meinhold, K., Simpson, A., Dupont, D., Kjems, J., Brown, A.C., LaBean, T. A functional RNA-Origami as Direct Thrombin Inhibitor with Fast-acting and Specific Single-Molecule Reversal Agents in vivo model. Molecular Therapy. 2024. Doi:10.1016 j.ymthe.2024.05.002.
  12. Nellenbach K., Nandi, S., Mihalko, E., Koch, D., Shetty, J., Sollinger, J., Moiseiwitsch, N., Sheridan, A., Hoffman, M., Schnabel, L., Lyon, A., Barker, T., and Brown, A.C.+ Ultrasoft platelet-like particles stop bleeding after trauma and exhibit unexpected clearance mechanisms. Science Translational Medicine. 2024. DOI: 10.1126/scitranslmed.adi4490
  13. Simpson, S., Krissanaprasit, A., Chester, D., LaBean, T., Brown, A.C.+ Utilizing multiscale engineered systems to examine TGFβ mediated myofibroblastic differentiation. 2024. Wound Repair and Regeneration. DOI: 10.1111/wrr.13168
  14. Davis, Z., Koch, D., Watson, S., Scull, G., Brown, A.C., Schnabel, L., Fisher, M + Controlled stiffness of direct-write, near-field electrospun gelatin fibers generates differences in tenocyte morphology and gene expression. Journal of Biomechanical Engineering. 2024. doi.org/10.1115/1.4065163.
  15. Kilgore R. E., Moore B. D., Sripada S. A., Chu W., Shastry S., Barbieri E., Hu S., Tian W., Petersen H., Mohammadifar M., Simpson A., Brown A.C., Lavoie J., Elhanafi D., Goletz S., Cheng K., Daniele M. A., Menegatti S. (2024). Peptide ligands for the universal purification of exosomes by affinity chromatography. Biotechnology and Bioengineering. doi.org/10.1002/bit.28821.

Other Publications by Lab Members:

  1. Liu S, Popowski K, Li J, Jing Y, Silkstone D, Belcher E, Cislo M, Hu S, Lutz H, Ghodsi A, Liu M, Dinh PUC, Cheng K*. Inhalable hsa-miR-30a-3p liposomes attenuate pulmonary fibrosis. Advanced Science. 27 Nov 2024.
  2. Li J, Sun S, Zhu D, Mei X, Huang K, Li Y, Liu S, Lyu Y, Wang Z, Hu S, Lutz H, Dinh PUC, Popowski K, Butte A, Cheng K*. Inhalable Stem Cell Exosome Modulates Endothelial CD36 for Enhanced Cardiac Repair in Rodent and Swine Models of Myocardial Infarction. Circulation. 01 Mar 2024.
  3. H.A. Miller, A. Priester, E. Curtis, K.Hilmas, A. Abbott, F. Kievit, A.J. Convertine. “Optimized gadolinium-DO3A loading in RAFT-polymerized copolymers for superior MR imaging of aging blood-brain barrier” Sensors and Diagnostics. (2024)

Paid REU Research Opportunity for Undergraduates!

This summer The Joint Department of Biomedical Engineering will be hosting a Summer Research Experience for undergraduate students that is supported through an institutional award from the American Heart Association. Applications are Due March 1st!

The research experience partners with NC State’s Comparative Medicine Institute (CMI), which has an extensive track record of developing technical and professional skills for undergraduates. The program engages participating undergraduates with in-depth research topics ranging from cardiovascular stem cell therapies to novel microelectronic implants. The curriculum also provides students with a broad background in areas related to cardiovascular biology and medicine, research methodology and team science. Each undergraduate participant will work directly with multiple faculty members, including potential mentors from the Joint Department of Biomedical Engineering, NC State College of Veterinary Medicine, College of Textiles and Comparative Medicine Institute, and their associated research groups.

See the link below for more information and to apply!

Brown Lab Member Awards and Recognitions for 2023

To start off 2024, we wanted to recap some of the highlights for Brown Lab members from the past year!

  •  Third-year PhD student Ana Sheridan was awarded the NSF GRFP award, a prestigious fellowship awarded by the National Science Foundation for early graduate researchers in the sciences.
  • Fifth-year PhD student Grant Scull was elected president of the National Student Chapter of SFB as well as a STAR award from the 2023 SFB National Meeting.
  • Fourth-year PhD Student  Aryssa Simpson earned the NCSU/UNC BME Student Service Award for her involvement as BME senator in the UNC Graduate and Professional Student Government, BMEGSA 2021-2022 Vice President and 2022-2023 Science Outreach Chair, and NC State representative of the Alliances for Graduate Education and the Professoriate (AGEP) for building infrastructure for faculty careers for underrepresented minority (URM) dissertation students.
  • In addition to defending her PhD thesis, MD-PhD student Nina Moiseiwitsch won a Cariovascular SIG Poster Award at the 2023 Society for Biomaterials (SFB)  Annual Meeting.
  • Second-year PhD Student Melika Osareh received support from the T32-funded Molecular Biotechnology Training Program (MBTP) aimed at training future academic, government, and industrial researchers interested in biotechnology.
  • First-year PhD student Ethan Pozy received support from the T32-funded Chemistry of Life Training Program (CLP) aimed at propelling research a the interface of molecular sciences and the life sciences .
  • Lab manager Jennifer Sollinger received and NCSU/UNC BME 2023 Award for Excellence for Excellence in Outstanding State Government Service for going above and beyond an employee’s normal responsibilities.
  • PI Ashley Brown was elected the titles American Institute for Medical and Biological Engineering (AIMBE) Fellow and American Heart Association (AHA) Fellow

 

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